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Stem Cell Biologist (Post Doctoral Research Differentation)
Stem Cell Biologist (Post Doctoral Research Differentation)
£31,983 - £41,773 per annum
National Institute for Biological Standards and Control, South Mimms
37.5 hours per week
FTC six month in the first instance

This is an opportunity to join the National Institute for Biological Standards and Control, a Centre of the Health Protection Agency (HPA), to undertake work in the area of stem cell biology, producing quality controlled stocks of stem cell lines to supply to scientists world-wide for research and for future therapeutic use. As part of this work, the UK Stem Cell Bank (UKSCB) collaborates closely with other laboratories within NIBSC, as well as with external laboratories throughout the UK and internationally. A position is now available for an experienced scientist to help advance these initiatives.

You will be involved in the development and optimisation of protocols for the differentiation of human stem cell lines and other associated cell lines. In addition, you will be involved the bank’s programme to improve of current cell banking, safety, quality control & characterisation methodologies. The work will involve working under quality management systems such as ISO 17025, 13485, EuGMP and is governed by HTA regulations.

Applicants should have a good degree in a biological science with either education to Post-Doctoral level or equivalent post-graduate experience. Skills in mammalian cell culture and/or molecular biology are essential. Experience of working in a cleanroom environment and within a quality system would be beneficial.

You should have good communication, organisational and time management skills, be self-motivating and enthusiastic with a willingness to learn new techniques.

The post is funded for six months in the first instance, with the possibility of extending this for a further three years.

For further details and to apply, please go to our website via the 'Apply Now' button.

Post Reference: 919-NIBSC-MM-7337310

Closing date: 15th September 2010

Interview Date: 12th and 14th October 2010

The Health Protection Agency is an equal opportunities employer.

Publ.Date : Tue, 31 Aug 2010 15:10:20 +0100

Stem Cell Biologist
Stem Cell Biologist
£26,749 - £35,805 per annum
National Institute for Biological Standards and Control, South Mimms
37.5 hours per week
FTC six month in the first instance

This is an opportunity to join the National Institute for Biological Standards and Control, a Centre of the Health Protection Agency (HPA), to undertake work in the area of stem cell biology, producing quality controlled stocks of stem cell lines to supply to scientists world-wide for research and for future therapeutic use. As part of this work, the UK Stem Cell Bank (UKSCB) collaborates closely with other laboratories within NIBSC, as well as with external laboratories throughout the UK and internationally. A position is now available for an experienced scientist to help advance these initiatives.

You will be involved in the preparation and quality assurance of banks of human stem cell lines, as well as the production of primary murine and human cells for potential use as feeder cells. In addition, you will undertake individual research project(s) as part of the continual programme of improvement to current UKSCB cell banking, safety, quality control and characterisation methodologies. The work will involve working under quality management systems such as ISO 17025, 13485, EuGMP and is governed by HTA regulations.

Applicants should have a good degree in a biological science with substantial experience in mammalian cell culture and/or molecular biology. Experience of working in a cleanroom environment and within a quality system would be beneficial.

You should have good communication, organisational and time management skills, be self-motivating and enthusiastic with a willingness to learn new techniques.

The post is funded for six months in the first instance, with the possibility of extending this for a further three years.

For further details and to apply, please go to our website via the 'Apply Now' button

Post Reference: 919-NIBSC-MM-5334160

Closing date: 15th September 2010

Interview Date: 12th and 14th October 2010

The Health Protection Agency is an equal opportunities employer

Publ.Date : Tue, 31 Aug 2010 15:08:22 +0100

Senior Immunologist
Pfizer Regenerative Medicine is a Research Unit within Pfizer with a spotlight on the application of stem cell biology towards developing new therapies for human disease, particularly cell based therapies. An important focus for the Unit are adult stems cells such as mesenchymal stem cells, and their potential application in allogeneic and autologous cell therapy for a variety of diseases, including those with an immune dysfunction basis and those with a vascular pathophysiology.

We are looking for an experienced immunologist to join the Pfizer Regenerative Medicine Research Unit. Your primary role will be in our adult stem cell therapy programme. One of your key areas will be to lead in the design and execution of studies focussing upon the mechanisms of interaction of adult stem cells with the immune system as an aid to understanding the biology underpinning their efficacy. There will also be the opportunity to consider novel approaches to biomarkers for cell function, and to explore the potential application of adult stem cell therapies to different disease states.

You will be expected to act as a resource in applying scientific knowledge to the work of other scientists in Pfizer Regenerative Medicine. You will be required to work independently as part of a larger team, and be accountable for the delivery and achievement of specific goals. The ability to form strong, productive collaborations with groups within Pfizer and external to Pfizer to enable the rapid progression of projects will be expected. You will also be expected to demonstrate flexibility in approach and to work in a fluid, entrepreneurial research environment. The candidate will be expected to make strong contributions to scientific discussions and will be expected to use their expertise towards the development of novel therapeutics for regenerative medicine

- Design and execution of studies and subsequent interpretation of data, with the goal of understanding the molecular and cellular mechanisms by which adult stem cells interact with and modulate the immune system.
- A broader intellectual contribution across the Research Unit as regards the interaction of the host immune system in the context of a range of cellular therapy modalities.
Ensure the quality of experimental data, results and methodology used.
- Have and maintain skills and experience to be fully conversant with the operation and validation of all items of equipment or IT needed for experimentation, data analysis, storage and data entry.
- Regularly use the scientific literature and electronic information critically to enhance understanding of technology area and generate novel methods and testable hypotheses.
- Build a strong relationship with key groups within Pfizer, and form strong, productive collaborations with academic groups and groups in companies outside of Pfizer

To apply, PLEASE FOLLOW THE ONLINE APPLICATION PROCESS. The requisition number for this vacancy is 943141.

Please include specific information regarding your skills and abilities for this particular role to assist us in assessing your suitability.

Please advise us if you have any particular needs to support your attendance and full participation in the interview. Likewise, if you would like written correspondence with you to feature a larger font size, please contact us on 01304 649922 or alternatively please detail the assistance you require on the bottom of your CV.

PLEASE DO NOT INCLUDE YOUR AGE OR DATE OF BIRTH IN YOUR RESUME/CV AS THIS INFORMATION IS NOT REQUIRED FOR YOUR APPLICATION

Qualifications:
- B.Sc in a biological science; PhD and postdoctoral experience in Immunology
- Expertise/ background in cell /molecular immunology
- Strong expertise the application of flow cytometric techniques, and cell based assays to investigate immune cell function
- Experience in mesenchymal stem cell biology, transplant biology, or adoptive transfer would be an advantage
- Works productively in matrixed teams
- Identifies and researches new opportunities proactively
- Uses available data and knowledge of the field to propose and test hypotheses
- Can present and defend data
- Respond well to questions, challenge and constructive feedback
- Willing to debate around his/her scientific choices, share the thinking
- Willing to learn from others and share own expertise with colleagues

PGRD's aim is to provide equality of opportunity in the recruitment process by avoiding discrimination on the grounds of: age, sex (physical characteristics you were born with), marital status, gender (self identity), sexual orientation, religion or belief, disability, colour, national or ethnic origin, political persuasion or trade union membership.

At Pfizer we are creating an organisation and promoting a culture that respects each individual's unique character and life experiences, and reflects the diversity of our customers and markets. We will achieve this through fostering and sustaining an environment in which every colleague feels valued and supported, thus enabling superior business results.

HOW TO APPLY:
Please copy and paste the following URL into your browser address bar:
http://posttrak.arbita.net/cgi-bin/PostTrak.cgi?RefCode=R9551420308643
Publ.Date : Wed, 18 Aug 2010 13:08:42 +0100

Stem Cell Biologist - Germany
Stem Cell Biologist - Germany

A leading Biotech company is currently seeking an experienced Stem Cell Scientist to join their R&D team in Hamburg, Germany. They are at cutting edge of the research and development of novel drugs in several therapeutic areas and are currently undergoing rapid growth. It is therefore an exciting time to be joining the company.

To be considered for this position you must hold a PhD in a relevant field and have several years experience, either as a post doc or in industry, working with human stem cell models. Your expertise and experience should be with the use and characterisation of human embryonic (ES) stem cell lines, ideally for the investigation of neurological disorders. You should be particularly experienced with cultivating and maintaining cell lines as well as gene expression analysis and protein expression studies. Ideally you will also have knowledge and expertise on iPS approaches (induced pluripotent stem cells).

In return the company are offering an extremely competitive salary package, including generous relocation package, healthcare, pension and bonus. If you think you have the required skills and experience, interviews will be taking place imminently, so apply now. For any queries please contact me, Don Le, at Paramount Recruitment, on 0121 616 3467

Research , drug discovery , therapeutic , biotech , chemistry , medicinal chemistry , discovery , oncology , CNS , inflammation , drugs , science , development , discovery , cancer , lab , laboratory , in vivo , drug development , central nervous system , in vitro , drug profiling , drug candidate , target identification , ex vivo , ex-vivo , stem cells , neurodegeneration , alzheimers , human stem cell models , human embryonic , ES , iPS , induced pluripotent , cultivation , gene expression , protein expression , neurological , neurology

Paramount Recruitment Limited provides services as an agency and an employment business. We regularly have similar roles in this area. Please see our website for details or send your CV in to us to find out the latest opportunities.
Publ.Date : Fri, 13 Aug 2010 09:53:02 +0100

Postdoctoral Research Fellow #51792
A Postdoctoral Research Fellow position is available in the Department of Hematopoietic Stem Cells and Leukemia Research, City of Hope National Medical Center. The laboratory is interested in cancer gene discovery and elucidation of underlying molecular mechanisms in hematologic malignancies, specifically in human lymphomas. We use molecular and cellular immunological techniques, human and mouse genetics, RNA interference technology and high-throughput screening approaches in tumor cell lines and animal models. The position requires experience in DNA cloning, mammalian tissue culture, retrovirus-mediated gene transfer, flow cytometry and microarray-based gene expression profiling. Familiarity with cellular immunology, tumor microenvironment and related fields is highly desirable. Candidates should be self-motivated, able to design and execute scientific experiments independently and willing to contribute to the laboratory as a team member. Please send a cover letter, curriculum vitae and contact information of three references to Vu Ngo, Ph.D. Department of Hematopoietic Stem Cell and Leukemia Research, City of Hope National Medical Center, 1500 E Duarte Rd, Duarte, CA 91010. Email: vngo@coh.org.
Publ.Date : Fri, 03 Sep 2010 00:09:55 +0100

Research Fellow - Translational Vaccine Research #51585
The Division of Translational Vaccine Research and the Department of Hematology have an exciting opportunity for a recent graduate interested in the study of immunologic mechanisms related to control of hematologic malignancy. The focus of the position is manipulation of human T cells specific for the WT1 antigen in lymphoma. The goal of this project is to develop a vaccine strategy for lymphoma patients based upon the WT1 antigen using viral and other vaccine delivery approaches. Most of the work will involve studies with human blood and marrow specimens, though work with murine models will be a minor component of this position. The ideal candidate will have experience with manipulations of primary human T cells including isolation and purification, cell culture, T cell functional assays including cytotoxicity assays and in vitro stimulation using peptides or viruses, LTCIC assays, and experience with flow cytometry, especially polychromatic flow using a modern 6-color instrument. The Transplant Unit conducts over 500 allo and auto stem cell transplants annually and is ranked 3rd highest in volume in the USA. Over 500 new lymphoma patients are accrued annually to the Hematology Department. A Ph.D. in immunology, applied clinical science, or cell biology is required, and experience with molecular approaches including virologic methods would be an advantage for the successful candidate.

Send CV, a summary of research experience/interests, and contact information for three references to Don J. Diamond, Ph.D. c/o: dpacker@coh.org, Beckman Research Institute of the City of Hope, 1500 E. Duarte Road, Duarte, CA 91010-3011.

Publ.Date : Wed, 25 Aug 2010 23:23:32 +0100

Stem Cell Biologist (Post Doctoral Research Scale - up)
Stem Cell Biologist (Post Doctoral Research Scale - up)
£31,983 - £41,773 per annum
National Institute for Biological Standards and Control, South Mimms
37.5 hours per week
FTC six month in the first instance

This is an opportunity to join the National Institute for Biological Standards and Control, a Centre of the Health Protection Agency (HPA), to undertake work in the area of stem cell biology, producing quality controlled stocks of stem cell lines to supply to scientists world-wide for research and for future therapeutic use. As part of this work, the UK Stem Cell Bank (UKSCB) collaborates closely with other laboratories within NIBSC, as well as with external laboratories throughout the UK and internationally. A position is now available for an experienced scientist to help advance these initiatives.

You will be involved in the development and optimisation of processes for scale –up and scale-out of banks of human stem cell lines and other associated primary cells and cell lines. In addition, you will be involved the bank’s programme to improve current cell banking, safety, quality control and characterisation methodologies. The work will involve working under quality management systems such as ISO 17025, 13485, EuGMP and is governed by HTA regulations.

Applicants should have a good degree in a biological science with either education to Post-Doctoral level or equivalent post-graduate experience. Skills in mammalian cell culture and/or molecular biology are essential. Experience of working in a cleanroom environment and within a quality system would be beneficial.

You should have good communication, organisational and time management skills, be self-motivating and enthusiastic with a willingness to learn new techniques.

The post is funded for six months in the first instance, with the possibility of extending this for a further three years.

For further details and to apply, please go to our website via the 'Apply Now' button

Post Reference: 919-NIBSC-MM-7337316

Closing date: 15th September 2010

Interview Date: 12th and 14th October 2010

The Health Protection Agency is an equal opportunities employer

Publ.Date : Tue, 31 Aug 2010 15:06:21 +0100

Manufacturing Associate - Mon-Fri or Tues-Sat
We are seeking an experienced research scientist in the field of Cell biology research, preferably human embryonic stem cell, to participate in California Institute for Regenerative Medicine (CIRM) and NHLBI funded programs focused on the development of suspension adaptation, scalable manufacturing processes, differentiation processes, manufacturing of clinical grade final cell products and characterization assays. The He/she will be part of a dynamic team and participate in the maintenance, expansion and differentiation of the hESC under research and cGMP conditions. He/she will also participate in the efforts on the characterization of the hESC and the differentiated cells, including cell surface/internal protein expression, expression of marker genes, genetic abnormality, and epigenetic fingerprinting of human embryonic stem cells. This is a high impact position within the nation’s premier academic cGMP manufacturing and translational research program at City of Hope’s Center for Biomedicine and Genetics. The successful candidate will have the opportunity to participate in the development of state of art technologies that will have an impact on translational research throughout the nation, potentially leading to the early clinical evaluation of many first-in-man hESC clinical trials. This position will interact with a team of scientist highly trained in stem cell research and GMP manufacturing of biological products.
Requirements
BS/MS degree with a minimal 3 years of research experience related to cell biology, preferably human embryonic stem cell.
Demonstrated skills in cell culture technique. Experience in hESC maintenance and differentiation is a plus. In addition, analytical skills, including FACS analysis of cellular markers, gene expression analysis by RT-QPCR are required.
Ability to work in a milestone-driven and team oriented environment and able to multi-task and work independently with minimal supervision.
Please submit your resume to sciencejobs@coh.org forconsideration.

Publ.Date : Mon, 09 Aug 2010 12:41:58 +0100

Clinical Research Scientist - Regenerative Medicine
• Integrates scientific knowledge and operational expertise to ensure excellence in the development and translation of clinical research plans into studies
• Responsible for clinical research, clinical review and oversight, representation on clinical study teams and decision-making
• Tracks emerging study data to ensure appropriateness of the chosen subject population and proactively assesses emerging data on an ongoing basis to ensure data quality
• Establishes relationships with key clinical experts/sites and uses this information to work jointly with CPM on site selection and patient recruitment
• For Regenerative Medicine stem cell studies, works closely with CPM and study manager to ensure that the specific requirements of these studies are reflected in risk management, monitoring and oversight plans and that novel endpoints can be appropriately captured on CRFs
• Is outward facing including learning/applying best practice from the external environment and is the key point of contact for clinical research
• Builds relationships with external investigators to promote scientific discussions, smooth operational delivery
• May recruit clinical investigators and negotiate study design
• Maintains a high degree of awareness of the external environment and ensures external innovations in scientific aspects and operational delivery are applied to the research portfolio
• Researches, evaluates and compiles scientific information
• Establishes scientific methods for the design and implementation of clinical protocols and final data reporting
• Responds and contributes to novel study designs and ensures these novel designs are optimized for operational effectiveness to ensure timely and cost-effective delivery
• Participates in the preparation of scientific presentations and manuscripts
Prepares clinical sections for documents required for the conduct of clinical studies, e.g., Clinical Investigator Brochures, IMPDs, IND documents etc
• Develops both scientific and operational expertise in novel techniques and trains others in their application
• Provides training to site study staff during the initiation visits and/or collective investigator meetings when beginning a new trial; assists in preparation of training materials
• Responsible for ongoing safety data review/monitoring and adverse event reporting
• Tracks emerging safety profile of the drug, keeping clinician informed of changes in the safety profile as they occur in the assigned study(ies)
• May act as consultant/liaison with partnering organizations

Organizational Relationships:
• Reports to the Clinical Lead Regenerative Medicine
• Accountable to research clinician for ensuring that scientific aspects of study fit within the overall clinical strategy
• Partners with the (CPM) to ensure study delivery
• Partners with biologists and other relevant team members to ensure appropriate method development and sourcing of human tissues/biofluids

Resources Managed (budget and FTEs):
• Responsible for appropriate use of allocated study budget

Training & Education Preferred:
• MD or PhD in scientific discipline or equivalent preferred; Masters degree acceptable
• Established record in execution of clinical trials in the pharmaceutical industry environment; experience in managing complex projects
• Relevant Therapeutic Area knowledge in regenerative medicine and experience with prior experience working with stem cells is a strong advantage.
• Comprehensive understanding of the drug development process with particular emphasis on Phase Ia/b / IIa/b clinical trials.

Technical Competencies:
• Comprehensive understanding of project management, clinical regulatory requirements, and knowledge of GCP and ICH guidelines
• Working understanding of PGRD infrastructure and processes is desirable, e.g., Pfizer SOPs, standards, goals and policies on business conduct
• Scientific excellence
• Demonstrated ability to design, initiate and conduct effective clinical studies applying novel principles as appropriate
• Ability to review and understand emerging data and proactively instigate measures to ensure delivery of quality study results

Behavioral Competencies:
• Acts Decisively - Makes timely and effective decisions by applying business and financial acumen. Makes decisions that translate into competitive advantage. Acts with urgency to deliver and removes barriers that hinder productivity Timely Decision Making – Makes effective decisions in a timely manner, often with incomplete information and under tight deadlines and pressure; able to evaluate risk and use this to inform decision making; does not prevaricate; actively seeks solutions to problems. Entrepreneurial and innovative; takes managed risks; thinks out of the box; challenges the status quo and dogma.

• Builds effective teams that can succeed in the adversity of drug discovery. Able to take teams through all stages of team development and willing to address matters that affect team performance. Blends people into teams when needed; creates strong morale and spirit in his/her team; shares wins and successes uses and builds on the expertise of others; fosters open dialogue; embraces diversity in the team; lets people finish and be responsible for their work; defines success in terms of whole team; maintains momentum through adversity.

• Accountability – For Self and Others - Takes personal accountability for outcomes. Sets the bar high for performance outcomes and holds others accountable for their commitments. Drives for results – Can be counted on to exceed goals; is constantly and consistently one of the top performers; very bottom-line oriented; steadfastly pushes self & others for results. Managing & measuring performance – clearly assigns responsibility for tasks and assignments; sets clear objectives and measures; monitors process, progress and results; designs feedback loops into work.

• Self Awareness - Recognises own strengths and limitations and personal motivations. Actively seeks feedback and knows one’s impact on others. Acts with authenticity and maturity. Self-knowledge – Knows personal strengths, weaknesses, opportunities and limits; seeks feedback; gains insight from mistakes; is open to criticism; isn’t defensive; is receptive to talking about shortcomings; looks forward to balanced performance reviews and career discussions; manages own confidence.

Benefits:
At Pfizer, we've long recognized that our colleagues are our most important asset. We value our colleagues, recognize their talent, encourage their growth and reward their performance. It's a terrific environment that enables people to contribute, to do their best, and to achieve their potential.

Throughout our history, a legacy of caring for others has been at the heart of everything we do at Pfizer. This commitment is no less important when it comes to our employees.

When you choose a Pfizer career, we provide the resources to help you develop and succeed both in your career and your personal life. One way we can achieve this is through our comprehensive benefits program, which offers employees and their eligible dependents the variety and flexibility to help address their needs at different stages in life.

Company Profile:
Pfizer Inc: Working together for a healthier world

Founded in 1849, Pfizer is the world's premier biopharmaceutical company taking new approaches to better health. We discover, develop, manufacture and deliver quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals. We also partner with healthcare providers, governments and local communities around the world to expand access to our medicines and to provide better quality health care and health system support. At Pfizer, colleagues in more than 90 countries work every day to help people stay happier and healthier longer and to reduce the human and economic burden of disease worldwide.

HOW TO APPLY:
Please copy and paste the following URL into your browser address bar:
http://posttrak.arbita.net/cgi-bin/PostTrak.cgi?RefCode=R7077420308543
Publ.Date : Wed, 28 Jul 2010 11:38:59 +0100

Senior Scientist - Genetics - Germany
Senior Scientist - Genetics - Germany

A leading Biotech company is currently seeking an experienced Stem Cell Scientists to join their R&D team in Hamburg, Germany. They are at cutting edge of the research and development of novel drugs in several therapeutic areas and are currently undergoing rapid growth. It is therefore an exciting time to be joining the company.

To be considered for this position you must hold a PhD in a relevant field and have several years experience, either as a post doc or in industry, working with human stem cell models. Your expertise and experience should be with the use and characterisation of human embryonic (ES) stem cell lines, ideally for the investigation of neurological disorders. You should be particularly experienced with cultivating and maintaining cell lines as well as gene expression analysis and protein expression studies. Ideally you will also have knowledge and expertise on iPS approaches (induced pluripotent stem cells).

They are looking for various people at different levels so both senior scientists with experience and PhD students with some post doc work should apply!

In return the company are offering an extremely competitive salary package, including generous relocation package, healthcare, pension and bonus. If you think you have the required skills and experience, interviews will be taking place imminently, so apply now. For any queries please contact me, Don Le, at Paramount Recruitment, on 0121 616 3467

Research , drug discovery , therapeutic , biotech , chemistry , medicinal chemistry , discovery , oncology , CNS , inflammation , drugs , science , development , discovery , cancer , lab , laboratory , in vivo , drug development , central nervous system , in vitro , drug profiling , drug candidate , target identification , ex vivo , ex-vivo , stem cells , neurodegeneration , alzheimers , human stem cell models , human embryonic , ES , iPS , induced pluripotent , cultivation , gene expression , protein expression , neurological , neurology

Paramount Recruitment Limited provides services as an agency and an employment business. We regularly have similar roles in this area. Please see our website for details or send your CV in to us to find out the latest opportunities.
Publ.Date : Thu, 12 Aug 2010 11:01:52 +0100

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